WebJan 1, 2007 · In the CFTR “life cycle”, there are four broad trafficking pathways that can be identified (i) biosynthesis, conformational maturation and trafficking from the endoplasmic reticulum (ER) to the plasma membrane, (ii) endocytic retrieval from the plasma membrane to early or sorting endosomes, (iii) recycling of endocytosed CFTR back to the cell … WebMar 30, 2024 · The reported biological effect on CFTR of indicated proteins is coded as follows: red: negatively affect CFTR stability, trafficking and/or activity; green: positively affect CFTR stability, trafficking and/or activity; black: unknown effects. Bold typeface indicates an increased expression change greater then 2-fold. Functional assignments ...
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WebCOMMD1 is a pleiotropic protein involved in CFTR trafficking, ionic exchanges in the airways surface liquid and inflammation inhibition. In our study, we show the anti ]inflammatory role of COMMD1 ... crazy paving look tiles
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WebRegulation of CFTR Trafficking by USP10. CFTR is a member of the ABC transporter superfamily and is responsible for chloride homeostasis across the cell membrane in epithelial cells. The surface expression of CFTR is tightly controlled by recycling in endosomes, where the ubiquitination of CFTR targets it to the lysosome for degradation. WebMar 17, 2024 · Low temperature (26–30 °C) partially restores F508delCFTR trafficking and channel function in cell lines, although the corrected channel has a lower open probability than wild-type CFTR 9. A... WebNational Center for Biotechnology Information crazy paws vet cohasset