WebThe first protein to be classified as a suppressor of cytokine signaling, CIS (cytokine-inducible SH2), was discovered in 1995, when it was found to have a unique ability to …

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WebThere are eight members of the CIS-SOCS family . Several reports have indicated that SOCS proteins are necessary for regulation of normal immune responses . SOCS proteins not only act as simple negative-feedback regulators, but they are also involved in fine-tuning the immune response and in the crosstalk of complicated cytokine signal networks. WebDec 10, 1999 · CIS, SOCS-2 and SOCS-3 were each found to bind specifically to tyrosine-phosphorylated GHR cytoplasmic tail sequences. This binding was observed in the absence of GH stimulation (Fig. 6), and thus does not require GH-induced tyrosine phosphorylation of the SOCS/CIS proteins or of any other signaling molecules. These results are most … includes grease oils plastics and soap

JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 …

WebSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that … WebJan 1, 2001 · Over the past few years, another family of cytokine-inducible proteins has been described. 23-29 Several of these proteins, which are variably called cytokine-inducible SH2-containing (CIS) proteins, SOCS, or SSIs, have been shown to be involved in the negative regulation of the Jak-STAT pathway. 28, 29 WebMar 30, 2005 · CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. incahurt