Cub domain-containing protein
WebJul 15, 2024 · This study advances CUB domain-containing protein 1 (CDCP1) as a novel target for metastatic castration-resistant prostate cancer, in both adenocarcinoma and neuroendocrine subtypes. Combined with low expression in normal human tissues, these data provide a compelling scientific rationale for translating CDCP1-directed RLT into the … CUB domain is an evolutionarily conserved protein domain. The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guida…
Cub domain-containing protein
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WebFeb 15, 2024 · CUB domain containing protein 1 (CDCP1), also known as Trask, gp140, SIMA135, and CD318, is a type I single-pass membrane protein that is highly overexpressed in a variety of solid tumors (12 – 14). WebAbstact. To measure the levels of serum CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in patients with ovarian cancer (OvCa), benign gynecological …
WebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. CDCP1 has also been designated as CD318 (cluster of differentiation … WebDec 31, 2012 · Cub domain containing protein 1 (CDCP1) is strongly expressed in tumors derived from lung, colon, ovary, or kidney. It is a membrane protein that is phosphorylated and then bound by Src family kinases. Although expression and phosphorylation of CDCP1 have been investigated in many tumor cell lines, the CDCP1 features responsible for …
WebDec 13, 2024 · Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ... XM_047418383.1 → XP_047274339.1 signal peptide, CUB and EGF-like domain-containing protein 3 isoform X4. XM_047418382.1 → XP_047274338.1 signal peptide, CUB and EGF-like domain … WebOct 3, 2024 · Abstract. Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein …
WebCUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix degradation during tumor invasion and metastasis in a tyrosine phosphorylation-dependent manner.
WebSep 1, 2009 · CUB and sushi domain-containing protein 3. Alternative names. CUB and sushi multiple domains protein 3; Gene names. Name. CSMD3. Synonyms. KIAA1894. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage. darwin hamilton groupWebSummary. This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. darwin had a phraseWebMar 28, 2011 · Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a secreted glycoprotein that is overexpressed in lung cancer tumor tissues and is correlated with the invasive ability in a lung ... bit by a brown recluse spiderWebAug 1, 2009 · The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and normal and malignant cells of different tissue origin, is not well defined. The contribution of CDCP1 to tumor metastasis was analyzed by using HeLa carcinoma cells … darwin hall obituaryWebDec 9, 2010 · CDCP1 Is Up-Regulated in Highly Metastatic Melanoma Cell Lines. CDCP1, also known as SIMA135 or Trask, is a transmembrane glycoprotein that contains three putative extracellular CUB domains. CUB domains are believed to function in protein–protein ( 22, 23) and protein/carbohydrate ( 24) interactions. We initially … bit by a chipmunkbit by a camelWebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and … darwin harbour