Development of the zebrafish inner ear

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August undefined, 2024

WebJan 4, 2024 · We find that hair and supporting cells from the zebrafish inner ear and lateral line are transcriptionally distinct, and that hair and supporting cells differ between the cristae and maculae. All of these distinct cell types are present during larval development and … WebThis dissertation focuses on the development and regulation of both sensory and neuronal cell populations. The sensory epithelium is established by the basic helixloop- helix transcription factor Atoh1. Misexpression of atoh1a in zebrafish results in induction of ectopic sensory epithelia albeit in limited regions of the inner ear.

Interpreting the Evolutionary Echoes of a Protein Complex …

WebJan 4, 2024 · The authors' main goal in the manuscript is to understand the diversity in hair cell and support cell subtypes in the zebrafish inner ear and their relationship to the mammalian inner ear. Overall, the manuscript's readability can be revised to improve the flow of the text, but there is sufficient information presented for readers to follow the ... WebFeb 1, 2016 · In this study, consistent with previous observations, the whole-mount in situ hybridization results clearly demonstrated the expression of HDAC1 in the developing inner ear of the zebrafish, suggesting the potential role of HDAC1 in the development of … list of v3 characters

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WebMay 1, 2024 · In particular, the Fgf8 gene plays an important role in the inner ear development of mice (Ratzan et al., 2024). Similarly, the loss of Fgf3 and Fgf8 in zebrafish causes the disappearance of ear tissues (Liu et al., 2003; Hans et al., 2007) and its downstream regulatory genes, such as SRY-Box transcription factor 9 (Sox9). WebApr 10, 2024 · In contrast, hair cells in the inner ear of zebrafish are produced throughout life and regenerate after trauma. However, it is unknown whether new sensory neurons are also formed in the adult zebrafish statoacoustic ganglion (SAG), the sensory ganglion … WebApr 1, 2002 · ... 5,6 The inner ear of zebrafish is composed of three pairs of semicircular canals (anterior, posterior and lateral) and two pairs of otolith organs named utricle and saccule. 6, 7 The... list of utf8 emojis

The zebrafish inner ear - ScienceDirect

WebOct 1, 2001 · Zebrafish do not posses any overt specialization of the inner ear (e.g., a cochlea) for hearing although they do have Weberian ossicles that are capable of transmitting vibration from the gas-filled swim bladder to the inner ear. Both the lateral line and the inner ear are used to detect vibrational stimuli in a manner that could be … WebApr 1, 2002 · Abstract Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several … list of utilities by stateWebIn the case of zebrafish, little is known about BMPs in inner ear development. It was reported that bmp2b, bmp4 and bmp7 are expressed in a discrete area of the otic epithelium, some of which correspond to sensory patches (Mowbray et al. 2001). However, the function of BMPs in semicircular canal development is still obscure. list of utm sources

"WebMar 21, 2002 · The early development of the zebrafish inner ear occurs rapidly beginning approximately 16 hr postfertilization (Haddon and … " - Development of the zebrafish inner ear

Development of the zebrafish inner ear

Effects of Toluene on the Development of the Inner Ear and

WebThis dissertation focuses on the development and regulation of both sensory and neuronal cell populations. The sensory epithelium is established by the basic helixloop- helix transcription factor Atoh1. Misexpression of atoh1a in zebrafish results in induction of … Web20 hours ago · That unexpected characteristic allows the hair cells to detect movement from the back of the fish with greater sensitivity than the front. "This shows that fish have hair cells that are actually ...

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Web2 days ago · Retinoic acid signaling has also been implicated in zebrafish ear development, specifically regulating the development of the semicircular canals and otoliths. Disruption of this pathway results in a circling behavior previously associated with inner ear malformations (Mackowetzky et al., 2024). WebZebrafish have lagena Birds have basilar papilla Mammals have organ of corti (cooked trochlea) When does inner ear development start? Week 4. When is inner ear functional? Week 22 . What determines the fate of the neural crest cells and preplacodal ectoderm in the neural plate?

WebFeb 1, 2016 · To investigate the function of HDAC activity during inner ear development, zebrafish embryos were continuously treated from 12 hours post fertilization (hpf) onwards with 0.1 μM TSA or 100 μM VPA. WebMay 23, 2014 · Chapter 3. Zebrafish Inner Ear Development and Function. Summary; 1. Introduction; 2. Development of the Zebrafish Inner Ear; 3. Zebrafish Hearing and Vestibular Function; 4. Disease Models; 5. New Technologies; 6. Conclusions and Future Directions; Chapter 4. Human Gene Discovery for Understanding Development of the …

WebMar 29, 2024 · The zebrafish model has been increasingly applied in understanding the molecular genetic principle of inner ear dysplasia and related diseases. 1, 2 The lateral line system is the sensory organ of zebrafish that detects water movements and sound, … WebOct 1, 2024 · Zebrafish models are widely utilized in studying inner ear development due to its rapid external embryonic development and optical clarity for observing the embryos (Whitfield et al., 2002; Wei et al., 2008). The inner ear structure of zebrafish is presented in Supplemental Fig. 1. In zebrafish, the precursors originate from the common pro ...

WebIn this chapter, we describe the anatomy of the zebrafish craniofacial skeleton; its applications as models for the mammalian jaw, middle ear, palate, and cranial sutures; the superior imaging technology available in fish that has provided unprecedented insights …

WebNov 30, 2001 · age of the development of the zebraﬁsh ear, highlighting the roles of genes identiﬁed by mutational studies and those with speciﬁc patterns of expression in the ear. These recent data complement detailed descriptions of the development and structure of the wild-type zebraﬁsh ear (Waterman and Bell, 1984; Platt, 1993; Haddon and immoweb century21 boondaelWebDec 31, 2014 · The zebrafish is now a well-established model for the study of the development, pathology, and regeneration of almost all vertebrate organ systems, and the inner ear is no exception. immoweb century 21WebAug 2, 2011 · Zebrafish have many benefits as a model animal for studying genes involved in inner ear development: first, zebrafish eggs develop in vitro; second, the zebrafish ear is transparent for the first few weeks of life; and third, forward genetic screens and antisense technology are well-established . The zebrafish inner ear system consists of ... list of uva ciosWebJan 1, 2014 · Development of the Zebrafish Inner Ear. The zebrafish embryo is beautifully suited to the study of the developing inner ear. The embryo itself is transparent, and the otic placode and vesicle are easily visible in the live embryo from the earliest stages of … immoweb century 21 decrolyWebFeb 21, 2024 · Gain-and loss-of-function studies in several vertebrate species have demonstrated a requirement for Gbx2 in development of … immoweb carteWebMar 21, 2002 · Although it remains a useful model of vertebrate otic morphogenesis, the developing zebrafish ear differs from that of an … list of vaccines needed for green cardWebDevelopment of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish. Journal of Neurobiology. 2000;43:329–337. The authors demonstrate that in larval zebrafish, the utricle but not … immoweb cerfontaine