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WebApr 10, 2024 · Next, we investigated the impact of chronic memantine or TC-G 1008 treatment on ELM, as well as on spatial memory (Morris water maze, MWM) in both WT and GPR39 KO mice. Following chronic experiments, we assessed hippocampal gene expression of targets previously associated with GPR39 by means of qRT-PCR. WebView memantine hydrochloride information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, directions for administration and drug action. WebMemantine enhances the anticoagulant effect of warfarin; additional INR monitoring should be carried out and warfarin dose adjusted accordingly. Drugs that increase the pH of the urine (e.g. sodium bicarbonate, carbonic anhydrase inhibitors) may reduce the elimination of memantine. Contraindications/Cautions - See SPC and BNFC for full details the park hotel tenby telephone number