Web12 Nov 2024 · However, sulfa-Michael addition (SMA) reactions remain a rather less explored reaction among asymmetric organocatalytic transformations, mainly because of the high nucleophilicity of thiols causing difficulties in controlling the stereoselectivity [21], despite C–S bond-forming reactions are of great interest in synthetic organic chemistry [22]. Web12 Nov 2024 · The target sulfa-Michael adducts were obtained with up to 96% ee under mild conditions and with a low (1 mol %) catalyst loading. Selected enantiomerically enriched …
Diastereodivergent Asymmetric Sulfa-Michael Additions of …
Web24 Feb 2024 · The reaction is conducted through sulfa-Michael addition reaction in the absence of solvent at 75°C within 2–3 h. The effects of different bases, molar ratio of … Web24 Nov 2024 · The reaction was conducted without any catalyst or additive under green conditions, i.e., ethanol as the solvent and at room temperature. In addition, the described robust method benefits from... ottawa live streamers
The synthesis of chiral β-naphthyl-β-sulfanyl ketones via ...
Web11 Feb 2016 · The reaction proceeds via one-pot oxidation – Michael addition mechanism and can serve as a useful addition to the existing methods for preparation of γ-keto sulfones based on Sulfa-Michael ... Web23 Jul 2024 · In summary, the first enantioselective sulfa-Michael addition of alkyl thiols to alkenyl benzimidazoles has been described. Excellent yields and good enantioselectivities … Web13 Oct 2009 · A common feature of all three structures is that they possess a highly electrophilic carbon centre (C-3 in 2 H-azirines, C-4 in conjugated nitroso- and azo-alkenes) that allows nucleophilic addition reactions to proceed very readily.In reactions of nucleophiles with 2 H-azirines this often leads eventually to opening of the three … ottawa live stream now