SpletTPC2 interactome data obtained by affinity precipitation of TPC2-eGFP-FLAG with anti-FLAG antibody from HEK293 cells. Heavily labeled proteins were from cells expressing TPC2-eGFP-FLAG and lightly labeled proteins were from cells expressing eGFP-FLAG. Proteins were eluted from beads by FLAG peptide. [doi:10.25345 ... Splet11. dec. 2024 · TCAs activate both TPC1 and TPC2 in a voltage-dependent manner, referred to as Ly sosomal Na+ channel V oltage-dependent A ctivators (LyNa-VAs). We also identified another compound which, like PI (3,5)P 2, activates TPC2 independent of voltage, suggesting the existence of agonist-specific gating mechanisms.
Endo-Lysosomal Two-Pore Channels and Their Protein Partners
SpletK Ca 3.1 K + channels reportedly contribute to the proliferation of breast tumor cells and may serve pro-tumor functions in the microenvironment. The putative interaction of K Ca 3.1 with major anti-cancer treatment strategies, which are based on cytotoxic drugs or radiotherapy, remains largely unexplored. We employed K Ca 3.1-proficient and -deficient … Splet02. dec. 2024 · View all data page: On the main page, users can follow the ‘View All Data’ link to download all interactome data as a CSV file or search for a SARS-CoV-2 protein and access its interactions. Viral protein selection can be done via the ‘Search’ section or via the filtering option in the ‘Microbial Protein’ column. skybokx 109 menu new orleans
The Two-pore channel (TPC) interactome unmasks isoform …
Splet16. feb. 2024 · SARS coronavirus 2 interactome. These page describe most significant functional host-virus interactions. Many more interactions have been suggested by large-scale or preliminary experiments and can be found in external resources. Host Protein. Splet25. avg. 2014 · As a result, the identification of NAADP-TPC2 interactomes is currently an area of great interest (Figure 2), and proteomic characterisation has unsurprisingly … Splet27. maj 2016 · We found that TPC2 serves as a negative regulator of pigmentation by increasing melanosomal membrane potential and acidity to decrease cellular melanin … swat specialist